De La Salle is located at 14600 Common Rd., in Warren, MI (48088).

The school is approximately 1/2 mile north of the Macomb County Community College 12 Mile campus, and approximately halfway between Schoenherr and Hayes Roads (which run north-south).

From the I-696 freeway, take the Bunert Rd. exit north to 12 Mile Rd., turn right (east) or 1/8 mile, and turn left on Gloede.

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